Continuous Flow Centrifuges

Pneumatic Scale Angelus, U. S. A

Carr Centritech Continuous Centrifuges (Separation Systems)

CARR Powerfuge P6

CARR P6 Powerfuge System provides continuous-flow two-phase separation of solids and liquids at rates up to 60 liters/hour. Using an innovative design, the feed is introduced through a stationary pipe and accelerated to full rotational speed before entering the titanium-alloy bowl. In this system, centrifugal forces as great as 20,000g permit separation of even sub-micron particles. Compressed solids are periodically removed with a fully-automated scraping cycle. After the solids have been discharged, automated CIP/SIP cycles can be performed via the PLC-controlled operating sequence. The P6 is designed for ease of operation, with sealed feed and drain lines allowing for aerosol-free operation. The P6 system meets cGMP and CE requirements and has been validated to meet chemical and pharmaceutical industry protocols.

CARR Powerfuge P12

CARR Centritech P12 Powerfuge System provides continuous flow two-phase separation of solids and liquids at rates up to 500 liters/hour for batches up to 4,000 liters. P12 is designed for ease operation, with seal feed and drain lines allowing for aerosol-free operation. Similarly, no special tools are required to disassemble the system. Integrated turnkey systems incorporating feed delivery options, CIP and SIP skids, temperature control, and closed-loop centrate pumping under vacuum are available. The P12 system meets cGMP and CE requirements and has been validated to meet chemical and pharmaceutical industry protocols. The P12 is engineered to optimize ease of operation while maximizing throughput; each step in the process can be readily automated so that the time spent on routine maintenance can be minimized

CARR Powerfuge P12

CARR Centritech P12 Powerfuge System provides continuous flow two-phase separation of solids and liquids at rates up to 500 liters/hour for batches up to 4,000 liters. P12 is designed for ease operation, with seal feed and drain lines allowing for aerosol-free operation. Similarly, no special tools are required to disassemble the system. Integrated turnkey systems incorporating feed delivery options, CIP and SIP skids, temperature control, and closed-loop centrate pumping under vacuum are available. The P12 system meets cGMP and CE requirements and has been validated to meet chemical and pharmaceutical industry protocols. The P12 is engineered to optimize ease of operation while maximizing throughput; each step in the process can be readily automated so that the time spent on routine maintenance can be minimized

CARR Powerfuge P18

CARR P18 Powerfuge System provides continuous-flow two-phase separation of solids and liquids at rates up to 1,700 liters/hour for batches up to 10,000 liters. The P18 is designed for ease of operation, with seal feed and drain lines allowing for aerosol-free operation. Similarly, no special tools are required to disassemble the system. Integrated turnkey systems incorporating feed delivery options, CIP and SIP skids, temperature control, and closed-loop centrate pumping under vacuum are available. The P18 system meets cGMP and requirements and has been validated to meet chemical and pharmaceutical industry protocols.

CARR UniFuge Pilot

CARR UniFuge utilizes a gamma irradiated, single-use module that requires NO CIP and NO SIP. All process contact surfaces are easy to install and are 100% replaceable after each run. Low shear harvesting of mammalian and insect cells is possible, and minimal reduction in viability of recovered cells is achievable. Since the cells are not lysed, production of cell debris in the centrifuge is minimized, making the UniFuge an excellent choice for both cell recovery or centrate clarification. UniFuge modules are readily tube welded to your single-use bioreactor connections. The UniFuge is completely automated with flexible cycle parameter entry. The feed suspension is gently pumped to the module and the cells settle to the outer radius while the clear supernatant is continuously discharged. Once the module has filled with cells, the controller stops the rotor and discharges the cells. This cycle is repeated until the bioreactor volume has been processed

CARR Viafuge V12

CARR Viafuge V12 Cell Separation System offers a major breakthrough in gentle cell separations, with no damage at medium to large-scale production levels. The continuous flor Viafuge V12 allows rapid cell harvesting and supernatant clarifications with unsurpassed viability, 99% recovery of intact cells, and up to 90% reduction in filtration needs. With flow rates up to 40 LPM and a variable speed drive, the Viafuge V12’s versatile performance characteristics enable the optimization of specific applications. Closed system operation allows recovery of concentrated cells and clarified supernatant without breaking containment. The Viafuge V12 facilitates cGMP compliance by offering a simple sanitary design including strategic placement of sprayballs and jets, ASME-rated configurations for steam sterilization and a flexible CIP/SIP software program

CARR Viafuge Pilot

CARR Viafuge Pilot is designed for fast, gentle, small- to medium-scale cell harvesting and supernatant recovery. Capable of separating a wide variety of mammalian and insect cells with little to no damage, the Viafuge Pilot offers intact cell recovery efficiencies in excess of 99% with non-detectable cell concentrations in clarified supernatant. The Viafuge Pilot’s unique design minimizes shear forces on cells. Incoming feed is matched to the bowl hub’s rotational velocity, allowing fast and efficient harvesting of even the most shear-sensitive cells without causing cell damage. Flexible operating conditions offer optimization for specific applications with a flow rate range of 0.1-4.0 L/min and a relative centrifugal force range of 500-10,000g.

CARR Powerfuge Pilot

There’s a point in discovery when you need efficient, high-volume product throughput. And at this point, dealing with bottles would impede productivity. This is precisely when you need the CARR Powerfuge Pilot, the high-productivity, batch liquid/solid separation system for bacteria, yeast, proteins and sub-micron particles with simple cleaning. The design helps reduce the time required for maintenance, particularly since there are few parts to replace. And when you’re at the end of a run, compressed solids are easily removed with minimal time and effort using a hand scraper contoured to fit the 1L capacity bowl. Fast processing at a rate of up to 1L per minute means that you can accomplish more runs in a single day, which is especially useful for larger batch sizes. And because the Powerfuge Pilot eliminates the need for bottles, you can set up runs in less time– with fewer manipulations. The Pilot has been equipped with a variable-speed drive. Users can select their desired flow rates of up to 60 L/hr and RCF to 20,000 g, providing the operational control necessary to optimize your process.

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